13 Research-Backed Ingredients
The MindSync Process™ combines the most powerful and unique Nootropic ingredients into one universal product:
- Components are carefully sourced in their most absorbable and bioavailable forms.
- Rigorous research methodology ensures that no theoretical compounds are utilized.
- Ingredients work synergistically to improve cognitive performance in multiple areas.
- Ingredients are effective at lower doses ensuring a compact and practical serving size.
- Broad efficacy and Nootropic usability across all age groups and demographics.
Citicoline as Cognizin®
CDP Choline is a compound made up of choline and cytidine (which converts into uridine) with neuroprotective and nootropic activity. CDP Choline decreases age-related memory impairment and cognitive decline, and enhances attention, learning and memory. CDP Choline also increases phosphatidylcholine production in the brain – an important component of cell membranes. CDP Choline also maintains neuronal membrane integrity and reduces neuronal death.
Weiss GB1 (1995). Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline. Life Sci. 1995;56(9):637-60. doi: 10.1016/0024-3205(94)00427-T
Fagone P & Jackowski S (2012). Phosphatidylcholine and the CDP-choline cycle. Biochim Biophys Acta, 1831(3):523-32. doi: 10.1016/j.bbalip.2012.09.009
Phosphatidylserine (PS) 70% from Sunflower Lecithin
Phosphatidylserine is a naturally occurring aminophospholipid found in high concentrations in the brain. Studies indicate its ability to reduce stress, fatigue, attention deficit and forgetfulness, and to increase mental processing speed and accuracy, attention and working memory. Phosphatidylserine has also been proven to increase NGF (nerve growth factor) activity and brain glucose metabolism.
Heiss WD, et al (1994). Long-term effects of phosphatidylserine, pyritinol, and cognitive training in Alzheimer’s disease. A neuropsychological, EEG, and PET investigation. Dement Geriatr Cogn Disord, 5(2):88-98. doi: 10.1159/000106702
De Simone R, et al (2003). Apoptotic PC12 cells exposing phosphatidylserine promote the production of anti-inflammatory and neuroprotective molecules by microglial cells. J Neuropathol Exp Neurol, 62(2):208-16. doi: 10.1093/jnen/62.2.208
Theacrine as TeaCrine®
Theacrine is a purine alkaloid found in the kucha Chinese tea plant (Camellia assamica). It is proven to increase mental clarity, energize workouts, and increase overall mood and motivation. Theacrine provides a long-lasting boost of energy, without any of the negative side effects (anxiety, insomnia, tolerance) associated with caffeine. It also activates the dopamine receptors DRD1 and DRD2, resulting in improved mood and help combat depression.
Ziegenfuss TN, Habowski SM, Sandrock JE, Kedia AW, Kerksick CM, Lopez HL. A Two-Part Approach to Examine the Effects of Theacrine (TeaCrine®) Supplementation on Oxygen Consumption, Hemodynamic Responses, and Subjective Measures of Cognitive and Psychometric Parameters. J Diet Suppl. 2016;1-15. doi: 10.1080/19390211.2016.1178678
Feduccia AA, Wang Y, Simms JA, et al. Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors. Pharmacol Biochem Behav. 2012;102(2):241-8.
L-Tyrosine as N-Acetyl-L-Tyrosine (NALT)
Acetyl-L-Tyrosine is an acetylated form of the amino acid L-Tyrosine with nootropic effects. It increases attention, motivation and concentration, and improves memory and learning. Tyrosine is a Dopamine precursor – it increases the synthesis of dopamine. Tyrosine also increases the synthesis of noradrenaline from dopamine, and balances the levels of Serotonin and GABA.
Topall G & Laborit H (1989). Brain tyrosine increases after treating with prodrugs: comparison with tyrosine. J Pharm Pharmacol, 41(11):789-91. doi: 10.1111/j.2042-7158.1989.tb06368.x
Fernstrom JD & Fernstrom MH (2007). Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. J Nutr, 137(6 Suppl 1):1539S-1547S. PMID: 17513421
Uridine is a naturally occurring nucleic acid that plays a key role in many different neuroregulatory processes. It is believed to support short and long term memory, learning, attention, and executive function. Uridine plays a key role in phospholipid synthesis, critical for cell membrane integrity. Uridine is also neuroprotective via its interaction with NGF (nerve growth factor) and other integrins and growth factors.
Dobolyi A, et al (2011). Uridine function in the central nervous system. Curr Top Med Chem, 11(8):1058-67. doi: 10.2174/156802611795347618
Wurtman RJ, et al (2010). Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses. Nutr Rev, 68 Suppl 2:S88-101. doi: 10.1111/j.1753-4887.2010.00344.x
B6 (Pyridoxal 5'-Phosphate) 45 mg
B9 (Methylfolate) 3 mg
B12 (Methylcobalamin) 3 mg
as nature-identical bioavailable vitamins
Vitamins B6, B9, and B12 have been shown to help balance homocysteine levels in a healthy range associated with a sharp overall mental performance. They have also been shown to promote mood balance, mental energy, information storage and long-range brain health. They also remedy mental performance concerns related to cognitive decline, brain aging, and poor blood flow to the brain. Vitamins B6, B9, and B12 also maintain the mood-balancing brain protector S−Adenosyl Methionine (SAMe), and form myelin, the fatty sheath that surrounds and protects all brain cells and nerves.
Deijen JB, van der Beek EJ, Orlebeke JF, van den Berg H. Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort. Psychopharmacology. 1992;109(4):489–496.
Homocysteine Lowering Trialists’ Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. BMJ. 1998 Mar 21; 316(7135): 894–898.
Schafer JH, Glass TA, Bolla KI, Mintz M, Jedlicka AE, Schwartz BS. Homocysteine and cognitive function in a population-based study of older adults. J Am Geriatr Soc. 2005;53(3):381–388.
Artichoke 4:1 Leaf and Stem Extract
Artichoke (Cynara cardunculus) is a plant that contains cynarin, having nootropic effects. Cynarin can significantly improve memory and executive function, in addition to logical, mathematical, and practical reasoning. It enhances working memory, short-term memory, memory consolidation, and memory recall. Cynarin is also synergistic with forskolin in increasing cAMP levels by inhibiting phosphodiesterase-4.
Li H, et al (2004). Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells. J Pharmacol Exp Ther, 310(3):926-32. doi: 10.1124/jpet.104.066639
Reneerkens OA, et al (2009). Selective phosphodiesterase inhibitors: a promising target for cognition enhancement. Psychopharmacology (Berl), 202(1-3):419-43. doi: 10.1007/s00213-008-1273-x
Forskolin Root Extract (20%)
Forskolin is a labdane diterpene and the main bioactive compound in Coleus forskohlii, having nootropic and adaptogenic effects. Forskolin improves learning, memory and mental stamina. Forskolin works synergistically with artichoke extract to boost intracellular levels of cAMP through adenylate cyclase activation – increased responsiveness to extracellular stimuli. Forskolin also inhibits acetylcholinesterase, increases acetylcholine levels, and decreases fatigue.
Yang QR, Wu HZ, Wang XM, Zou GA, Liu YW (2006). Three new diterpenoids from Coleus forskohlii Briq. J Asian Nat Prod Res, 8(4):355-60. doi: 10.1080/10286020500172236
Henderson S, et al (2005). Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. J Int Soc Sports Nutr, 2:54-62. doi: 10.1186/1550-2783-2-2-54
Huperzine-A Extract (1%)
Huperzine A is a potent natural synaptic enzyme modulator from a Chinese club moss called Huperzia serrata. Studies indicate its ability to support learning, memory, neuroplasticity, and executive function. Huperzine-A is an acetylcholinesterase inhibitor that supports memory consolidation and neuroplasticity. It is also neurogenic through increased proliferation of hippocampal neural stem cells and NGF (nerve growth factor) stimulation.
Wang R, et al (2006). Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta Pharmacol Sin, 27(1):1-26. doi: 10.1111/j.1745-7254.2006.00255.x
Ma T, et al (2013). Huperzine A promotes hippocampal neurogenesis in vitro and in vivo. Brain Res, 1506:35-43. doi: 10.1016/j.brainres.2013.02.026
PQQ is a quinone molecule with a potent anti-oxidant and neuroprotective effect. Studies indicate that PQQ can increase mitochondrial energy and help prevent cognitive decline. PQQ increases the production of mitochondria and improves their efficiency, and can act as a growth factor after prolonged intake. It also increases NGF (nerve growth factor) synthesis, promoting neuronal growth and survival.
Chowanadisai W, et al (2010). Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem, 285(1):142-52. doi: 10.1074/jbc.M109.030130
Yamaguchi K, et al (1993). Stimulation of nerve growth factor production by pyrroloquinoline quinone and its derivatives in vitro and in vivo. Biosci Biotechnol Biochem, 57(7):1231-3. doi: 10.1271/bbb.57.1231
N-Phenylacetyl-L-Prolyglycine Ethyl Ester (Noopept)
Noopept is a potent receptor site modulator and nootropic. Studies indicate its ability to increase memory and attention span, reduce worry and improve mood, and exhibit neuroprotective qualities. Noopept upregulates neurotrophin factors NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor), involved in neurogenesis and long term memory. It also modulates EEG patterns in ways considered positive for calm alertness.
Ostrovskaya RU et al (2008). Noopept stimulates the expression of NGF and BDNF in rat hippocampus. Bull Exp Biol Med, 146(3):334-7. doi: 10.1007/s10517-008-0297
Kondratenko RV, et al (2010). Novel nootropic dipeptide Noopept increases inhibitory synaptic transmission in CA1 pyramidal cells. Neurosci Lett, 476(2):70-3. doi: 10.1016/j.neulet.2010.04.005